ABSTRACTAcoustical properties have been measured for substituted heterocyclic drug (Lovastatin) in DMSO at different temperature. The measurement have been perform to evaluate acoustical parameter such as adiabatic compressibility, Partial molal volume (Pv), intermolecular free length (Lf), apparent molal compressibility, specific acoustic impedance (Z), relative association (RA), salvation number (Sn) and also studied the molar polarization.KEY WORDS: Molar polarization, Polarizability constant, Ultrasonic velocity, Intermolecular free length, Relative association.

ABSTRACTA

compound (AP-I) was isolated from the leaves of Abrus precatorius Linnaeus by solvent extraction, acid hydrolysis, chromatography followed by crystallization. The compound could exert body weight loss in rats. Reduction of body weight of the rats by this compound started from 10th day but significant reduction was observed from 20th day onwards. Effect of seasons on the amount of isolated compound (AP-I) from A. precatorius L. leaves was also studied. Results showed that leaves of A. precatorius L. for the months of July and August yielded maximum amount of the compound.

KEY WORDS: Abrus precatorius Linnaeus, Acid hydrolysis, Chromatography, AP-I.

ABSTRACTIn the present study, the crab, O. senex senex was injected with V. harveyi (0.1 ml of 108 cfu/ml). After injection of bacteria the crabs were allowed to withstand for 96 hrs. After 96 hrs in one group of crab’s haemolymph were used for haematological and immunological assays. Remaining bacterial injected crabs were treated with 0.05 ml of 80% P. guajava leaf ethanol extract (1000 ppm ) , after 96 hours Total Haemocyte Count (THC) and Prophenol oxidase (ProPO) were significantly changed (P<0.001 ) in the experimental group. These results suggested that the P. guajava could combat the microbial infection by stimulating the immune response in crabs.KEY WORDS: THC, Haemocytes, ProPO, P. guajava, V. harveyi, O. senex senex.

ABSTRACTAim to study the unusual trifurcation of brachial artery. 100 upper limbs of 50 donated embalmed cadavers (45 males & 5 females) of age group ranging from 70 to 80 years were dissected in the department of Anatomy at K. J. Somaiya Medical College, Sion, Mumbai, INDIA. The unusual trifurcation of brachial artery was observed in 2 specimens. The neuro-mascular pattern in the arm was also observed. The photographs of the unusual trifurcation of brachial artery were taken for proper documentation. The unusual trifurcation of brachial artery was observed in 2 specimens. The brachial artery trifurcated into radial, ulnar and common interosseous arteries. The knowledge of unusual trifurcation of brachial artery is clinically important for clinicians, surgeons, orthopaedicians and radiologists performing angiographic studies.KEY WORDS: Brachial artery, Trifurcation, Radial, Ulnar and Common interosseous arteries.

ABSTRACTAim to study the variant Flexor Carpi Ulnaris muscle. 100 upper limbs of 50 donated embalmed cadavers (45 males & 5 females) of age group ranging from 70 to 80 years were dissected in the department of Anatomy at K. J. Somaiya Medical College, Sion, Mumbai, INDIA. The variant Flexor Carpi Ulnaris muscle was observed in 2 specimens. The neurovascular pattern was also observed. The photographs of the variation of the Flexor Carpi Ulnaris muscle were taken for proper documentation. The separate humeral and ulnar heads of flexor carpi ulnaris muscle were observed in 2 specimens. The ulnar head of flexor carpi ulnaris muscle was more bulky. It separated ulnar nerve and artery. The humeral and ulnar heads were separated from each other by ulnar nerve. These two heads fused with each other just before their insertion, where the ulnar artery came in contact wih ulnar nerve. The further course and distribution of ulnar artery and ulnar nerve were normal. The knowledge of such unusual ulnar head separating ulnar artery and ulnar nerve may be clinically important for plastic surgeons doing flap surgeries and for the surgeon dealing with cubital tunnel syndrome.KEY WORDS: Flexor carpi ulnaris, Ulnar artery, Ulnar Head, Ulnar nerve, Humeral head, plastic surgeons, cubital tunnel syndrome.

ABSTRACTCurrently used modern medicines for various ailments were associated with adverse effects and withdrawal leads to rebound phenomenon which is not seen with herbal preparations. Plant parts or plant extract are sometimes even more potent than known modern drugs. Taking these finding in considerations its mandatory to develop an alternate to modern drugs in plant origin. Limonia acidissima L. Swingle Syn. Feronia elephantum Correa, Schinus Limonia L. (Rutaceae), is a tropical plant species, indigenous to India and locally known as elephant apple. All the parts of Limonia are prescribed in indigenous system of medicine for the treatment of various ailments. The present study was conducted to evaluate the antihyperlipidemic activity of ethanolic leaf extract of Limonia acidissima in high fat diet induced hyperlipidemia rats. The rats were divided into 5 groups of 6 animals each. The animals of all the groups except normal group were given a high cholesterol diet consisting of 2% cholesterol, 1% cholic acid and 2 ml coconut with standard pellet diet for 30 days. The first group served as normal control received 0.5% Carboxy Methyl Cellulose orally for 30 days. The second group served as hyperlipidemic control, was given High cholesterol diet while the third group was treated with ethanolic leaf extract of Limonia acidissima (200 mg/kg, p.o.), once a day for 30 days. The fourth group was treated with Atorvastatin suspension prepared with 0.5% CMC (10mg/kg; p.o.), once a day for 30 days. Hyperlipidemia was induced by high cholesterol diet consisting of 2% cholesterol, 1% cholic acid and 2 ml coconut oil with standard pellet diet for 30 days. On 31st day the serum was subjected to various biochemical tests like Total Choleserol, Triglyceride, HDL-C, and LDL-C, VLDL-C. The results showed that there was significant decrease in Total Choleserol, Triglyceride, LDL and VLDL and increase in HDL. From the result it was concluded that the ethanolic leaf extract of Limonia acidissima exhibit antihyperlipidemic activity.KEY WORDS: Limonia acidissima, Hyperlipidemia and Atorvastatin.

ABSTRACTThe present research work was carried out with the aim to prepare and evaluate sustain release pellets of Ambroxol HCl, a drug which is used as mucolytic agent. The basic goal is to sustain the drug release upto 24hours. Pellets have been prepared by Wurster process employing different viscosity grades of ethyl cellulose as polymer for sustain drug release and diethyl phthalate, propylene glycol and triethyl citrate as plasticizer in the formulations. Total of 16 formulations have been developed by varying polymer and plasticizer concentrations. Physical compatibility studies revealed that there is no incompatibility between drug and excipients. Micromeritic properties revealed the good flow properties of the pellets. The friability and drug content were within the specified limits. The formulated pellets have low moisture content and are suitable for filling into hard gelatin capsules. From the in-vitro dissolution profile formulation (F11) containing Ethyl Cellulose 50cps and propylene glycol were found to produce the drug release similar to innovator product along with all the parameters, so it is optimized and subjected to stability studies and found that there was no significant change in the properties of the pellets.KEY WORDS: Sustain release pellets, Ambroxol HCl, Mucolytic agent, Wurster process, Diethyl phthalate, Propylene glycol, Triethyl citrate.

ABSTRACTEstablishment of an efficient tissue culture in – vitro protocol is an essential prerequisite in harnessing the advantage of cell and tissue culture for genetic improvement. The application of advanced tissue culture techniques may lead to new avenues in crop improvement. Rice is an important cereal crop and is the primary source of food. Present study was aimed to develop an efficient and reproducible regeneration system through somatic embryogenesis from scutellar embryo derived calli of rice i.e. APMS – 6B. Calli were maintained and after some weeks by subculturing they were transferred onto modified MS and N6 media and supplemented with different concentration of BAP and NAA. Shoot regeneration percent for somatic embryogenesis was successfully obtained and transplantation was performed.KEY WORDS: Somatic embryogenesis, Plant regeneration, Callus, Shoot regeneration.

ABSTRACTCarbon storage by dominant tree species in Khrunti Model Plantation site of TATA Steel at KPO near Duburi was quantified to assess the magnitude and role of plantation in combating the rise of carbon dioxide in the ambient air. The Above Ground Biomass (AGB) and Above Ground Carbon (AGC) of each species were assessed to evaluate the carbon dioxide equivalent of each species. The AGB ranged from 2.85 tonnes/ha (in Sweitenia mahogani) to 54.33 tonnes/ha (in Lagerstroemia indica) during premonsoon while the minimum and maximum values of AGB were 3.57 tonnes/ha (in Sweitenia mahogani) and 61.71 tonnes/ha (in Lagerstroemia indica) respectively during monsoon. The AGC ranged from 1.33 tonnes/ha (in Sweitenia mahogani) to 24.94 tonnes/ha (in Lagerstroemia indica) during premonsoon while in monsoon season the minimum and maximum values of AGC were 1.60 tonnes/ha (in Tabebuia sp.) and 26.66 tonnes/ha (in Lagerstroemia indica) respectively. Few trees of Bakul (Mimusops elengi) were not being considered in the study because of their stunted growth and DBH < 20 cm. The highly acidic soil may be one of the reasons behind the low AGB and subsequent AGC of the species in the plantation site.KEY WORDS: Khrunti Model Plantation Site, Above Ground Biomass (AGB), Above Ground Carbon (AGC), Carbon dioxide- equivalent.

ABSTRACT In this study, pathogenic microorganisms were isolated from wound samples of patients, who were followed up in different clinics of Amasya University, Sabuncuoglu Serafettin Training and Research Hospital between January, 2012 and January, 2015. The aim of the study is to assess these microorganisms retrospectively as well as detect their antibiotic resistance status. The wound samples, which were sent to our microbiology laboratory from various clinics of the hospital, were seeded with the help of classical techniques and strains were isolated from them. The isolates were identified and their antibiotic resistances were determined by using VITEK 2 (BioMerieux, French) automatic system. Out of 712 bacteria, the 411 of them (57.7%) were Gram positive bacteria whereas 301 of them (42.3%) were Gram negative bacteria. The isolation frequencies of bacteria were 33%, 21.4%, 13.6%, 9.4%, 8.4% and 4,2% for coagulase-negative staphylococci (CNS), S. aureus, E. coli, P. aeruginosa, A. baumannii and K. pneumoniae; respectively. The 7.1% of the S. aureus strains and 55.8% of CNS were methicillin resistant whereas they were not resistant against vancomycin. It has been detected that amikacin is the most effective antibiotic for the isolated Gram negative bacteria. While planning the treatment plan of wound infections, it is recommended that the appropriate antibiotic selection can be made mainly by considering the types of infectious agents and their antibiotic sensitivities.KEY WORDS: Wound culture, Antibiotic resistance.